Alongside prop forward Craig Huby, returning to the squad are Man of Steel Rangi Chase, club captain Danny Orr, full back Richard Owen, winger Nick Youngquest, and fellow props Grant Millington and Nathan Massey.
Making way for the returning players are hooker Ryan Hudson, back rows Lee Mitchell, James Grehan & John Davies, prop Steve Nash, winger Josh Atkinson, plus James Clare and Ben Johnson who both were non-playing members of Monday's squad.
Jordan Thompson and Adam Milner, retain their places having impressed against St Helens on Monday. On naming his squad, head coach Ian Millward said:
"It's a knock out game so no one is going to worry about for or against. It's all about what happens on the day. The environment will be intense; a great atmosphere which is fantastic for the players. It will be interesting to see which team handles it the best.
"It is a big game, but our main focus is about getting through to the next round of the Challenge Cup. I'm very confident if we put our best foot forward then we can achieve that."
Featherstone Rovers winger Tommy Saxton is relishing the chance to halt home-town club Castleford Tigers' dreams of Carnegie Challenge Cup victory when they go head-to-head in the fourth round on Saturday April 14 (3.00pm) at The Big Fellas Stadium.
Born and bred in Castleford, Saxton can't wait to take on the team he started his career with and the powerful winger, a 2005 Challenge Cup final winner with Hull FC, is hoping to prove a point.
"Out of all the teams to play in the fourth round I was hoping for Castleford," said Saxton. "Not only for personal reasons but it's great for the club as well. Hopefully it will be a sell-out crowd and the atmosphere will be fantastic, I'm really looking forward to it.
"I'm glad we're at home as I think the crowd will be an extra man out there for us and help intimidate the Castleford players. I played for Cas a long time ago but it would be nice to get the win and prove my mates who are Tigers fans wrong.
"Realistically it's going to be a tough match, they are full time and that can play a big part. But if they play their best and we play our best on the day then who knows what will happen with the magic of the Cup."
Featherstone first team squad: Bostock, Briggs, Carr, Chappell, Dale, Dickens, England, Finn, Freer, Grayshon, Haley, Hardman, Hemingway, Hepworth, Kain, Kaye, Lockwood, Maloney, Muvududu, Ropati, Saxton, Smeaton, Spears, Worthington
Castleford Squad: Owen, Youngquest, Dixon, Griffin, Chase, Orr, Emmitt, Clark, Huby, Ferres, Walker, Snitch, Jones, Milner, Millington, Holmes, Massey, Mcgoldrick, Thompson.