Old foes Wigan and St Helens have been drawn together in the quarter-finals of the Carnegie Challenge Cup.
Championship minnows Leigh have been rewarded with a home tie against Leeds, while Huddersfield will entertain the London Broncos and Warrington face a tricky tie away against Catalan Dragons.
However it was the derby pairing of arch-rivals Wigan and Saints, who met in the 2004 final, that was the highlight of the draw, with ties to be played on the weekend of May 11-13.
St Helens have not failed to reach the semi-finals for 11 years but they will be severely tested by the defending champions, who won 28-10 at Langtree Park on Good Friday.
That was Saints' only defeat in seven matches since caretaker coaches Mike Rush and Keiron Cunningham took charge following the sacking of Royce Simmons.
Super League champions Leeds, who lost to Wigan in last season's final, will be wary of underestimating Leigh in their tie.
Table-topping Huddersfield will fancy their chances of advancing to the last four, especially given the Broncos' poor away form.
Nothing is so certain for Warrington, though, with the 2009 and 2010 champions having lost 44-16 away to the Dragons on Easter Monday.
Full draw: Huddersfield v London Broncos, Catalan Dragons v Warrington, Leigh v Leeds, Wigan v St Helens