Wigan crushed injury-hit Hull 48-10 in a ruthless display to move five points clear at the top of the Stobart Super League.
Josh Charnley scored his fourth hat-trick of the season as the Warriors ran in nine tries against the Black and Whites.
Hull battled bravely and to the finish but their third game in eight days proved a step too far for a side which finished the game with just 14 fit players.
Hull were especially badly hit by the late withdrawals of Jordan Turner and Danny Houghton and they also lost England centre Kirk Yeaman with an ankle injury midway through the first half, while forwards Jay Pitts and Liam Watts also failed to finish the game.
Wigan took just two minutes to open their account after Gareth Hock was fortunate to earn a penalty after he appeared to lose the ball, Sam Tomkins jinking his way over from 10 metres out.
Tomkins turned creator on 10 minutes as his break and offload to George Carmont set up Hock to score and five minutes later the full-back's cut-out pass put Charnley in at the corner.
Hull were reeling and when the ball was swung out to the right again, Charnley was able to dive in unopposed for his second try.
Only some sloppy Wigan handling was keeping Hull in the game and the visitors took advantage just past the half-hour, when Harrison Hansen spilled the ball and moments later Tom Lineham was able to get in at the corner.
At 18-4 Hull were still in the contest but on the stroke of half-time, Matty Smith's diagonal grubber kick sat up perfectly for Tomkins to score.
From then on it was just a question of how and how many, although just after the break Tomkins did bomb a chance to score his hat-trick when he dropped Hansen's scoring pass.
But Charnley made no mistake when Jack Hughes broke through, the winger on his shoulder to take the pass and run in unopposed.
Smith dummied his way through the defence to put Liam Farrell in and Michael McIlorum busted over from close range, and although Brett Seymour grabbed a late try for Hull, Sam Powell had the final word for Wigan on his debut, a neat dummy and step taking the teenager in beneath the sticks.