Wigan have included full-back Sam Tomkins in their 19-man squad for Sunday's visit of London after he missed last week's defeat at Huddersfield with a shoulder problem.
Second rower Chris Tuson makes his first appearance of the season for the Warriors after recovering from a quad injury. Centre Darrell Goulding is ill and winger Anthony Gelling injured.
Veteran hooker Ben Fisher is set to make his debut for London. Fisher, who turned 32 earlier this month, joined the Broncos as assistant coach at the end of last season but the club took the precaution of lodging his playing registration with the Rugby Football League.
"It was always part of our plans, it was an option from day one," said London head coach Tony Rea. "He's looked sharp in training this week."
Fisher, an Australian-born Scotland international, made 124 Super League appearances for Hull KR from 2007-11 and made 14 appearances for Catalan Dragons last year.
Utility back Dan Sarginson is in line for his first appearance of the season after gaining match fitness with Hemel Stags.
Full-back Luke Dorn returns in place of Michael Robertson while Alex Hurst and Jamie O'Callaghan also miss out.
The Broncos are one of only two clubs yet to win a match after the first three rounds of Super League.
Wigan squad: Burke, Charnley, Crosby, Dudson, Farrell, Flower, Green, Hughes, McIlorum, Mossop, O'Loughlin, Powell, Richards, Smith, Taylor, Thornley, L Tomkins, S Tomkins, Tuson
London squad: Bailey, Bryant, Channing, Cook, Colbon, Dixon, Dorn, Fisher, Gower, Kaufusi, Krasniqi, Lee, Melling, Randall, Rodney, Sarginson, Wheeldon, Witt, Lovell