Michael McIlorum and Joe Burgess return to the Wigan squad, after both were rested on Easter Monday.
The duo come in for Anthony Gelling, who misses out through suspension, and injured Joel Tomkins (foot), while ex-Catalans players Morgan Escare and Romain Navarette are likely to feature.
Catalans' injury list has grown with centre Krisnan Inu and back-rower Justin Horo ruled out.
Alrix Da Costa and Ugo Perez come into the squad as replacements.
Wigan: Bretherton, Burgess, Davies, Escare, Farrell, Flower, Forsyth, Gregson, Isa, Leuluai, Marshall, Mcilorum, Navarrete, Nuuausala, O'Loughlin, Powell, Sutton, Tautai, Williams.
Catalans: Gigot, Yaha, Walsh, Myler, Moa, Aiton, Casty, Anderson, Bousquet, Garcia, Bosc, Duport, Simon, Thornley, Albert, Da Costa, Margalet, Belmas, Perez