Controversial hooker Scott Moore begins his second spell with Huddersfield on Sunday after being named in coach Nathan Brown's team.
Brown is resting several players, including captain Kevin Brown and winger Jermaine McGillvary.
Huddersfield born-and-bred brothers Darren and Ritchie Hawkyard will line up alongside each other for Swinton.
Former Warrington and Super League Dream Team winger Kevin Penny is also in the Lions' squad.
Swinton found it tough going at the same stage of this competition last season when high-flying Warrington beat them by a record 112-0.
Nathan Brown told Radio Leeds "We're hopeful of putting in a good performance and getting our name in the hat for the next round.
"I'm sure that our disappointments in this competition will stand us in good stead.
"They come here with nothing to lose and that can be dangerous. A couple of their players will be looking to put themselves in the shop window.
"We need to show them the respect they deserve."
Huddersfield: Grix, Lawrence, Cudjoe, Gilmour, Brough, Robinson, Mason, O'Donnell, Fa'alogo, Faiumu, Ferguson, Wardle, Chan, George, Murphy, Molloy, Cording, Eden, Moore.
Swinton: R. Hawkyard, Mort, Reay, Armstrong, Penny, M. Ainscough, Watson, Mills, M. Smith, Meekin, Cunniffe, D. Hawkyard, I'Anson, Ashall, Riley, Morrison, Clarke, N. Holland, Wingfield.