Leigh won 32-18 at Halifax in the Championship last week, ending a four-match winning streak for Karl Harrison's side.
The result prompted Fax coach Harrison to review his planned preparation for this weekend's Cup tie at Leigh.
The potential reward of a money-spinning quarter-final against a Super League club means neither side will lack for motivation.
Coach Karl Harrison wants Halifax back on "the big stage".
Karl Harrison told Radio Leeds "I said before the draw that I wanted the easiest tie going, that wasn't to be but we're happy anyway.
"We were poor last week but we still weren't a million miles away.
"We want to be in the next round of this competition. We want to be back on the big stage.
"They're very physical, especially in the middle of the park so we need to be mindful of that."
Leigh: McNally, Maden, Littler, Gardner, Pownall, Ridyard, Duffy, Hopkins, Goulden, Parker, Nash, Taylor, Ostick, Brierley, Briscoe, Laithwaite, Beswick, Gallagher, Nicholson.
Halifax: Ambler, Ashall, S. Barlow, Casey, Divorty, Fieldhouse, Gannon, Handforth, Heaton, Hesketh, Manning, Morrison, Paterson, Penkywicz, Reittie, Robinson, Thackery, Tyrer, Worrincy.