Batley coach John Kear has drafted Castleford Tigers' loanee James Grehan into the squad, with second-rower Johnny Walker a doubt.
With Mark Toohey and Adam Scott also injured, Alex Bretherton is the only other fit second-rower.
London Broncos are without Liam Colbon (shoulder), Tony Clubb (groin), David Howell (thumb), Julien Rinaldi (ankle) and Jason Golden (ribs).
However Michael Robertson, Michael Witt and Karl Temata all return.
John Kear told Radio Leeds "When you analyse it, we're at home and they're the lowest ranked Super League side left in it. It's an interesting tie.
"We like being the underdogs and there's a sense of anticipation here
.
"We need to do our preparation on the pitch, if that churns it up then so be it.
"I want out fans to make it a hostile environment for them to come to. They're not going to enjoy it here."
Batley: Preece, Brown, Walton, Maun, Potts, Black, Moore, Smith, Mennell, Potter, Bretherton, Walker, Applegarth, Walmsley, Hirst, Grehan, Lythe, Lindsey, Palfrey.
London Broncos: Bailey, B. Bolger, Caro, Bryant, Channing, Cook, Dixon, Dorn, Gower, Kaufusi, Krasniqi, Melling, O'Callaghan, Randall, Rodney, Robertson, Sarginson, Temata, Witt.