Leeds have included youngsters Ashton Golding and Ash Handley in their squad for Sunday's trip to Widnes.
The Rhinos are still without Beau Falloon after the hooker broke his toe in training while skipper Danny McGuire has been ruled out for up to two months with a knee injury.
Rob Burrow takes over the captaincy while Josh Walters could also feature as the Rhinos seek a return to winning ways.
Widnes opened their campaign with victory at Wakefield last Sunday and head coach Denis Betts brings Stefan Marsh onto the wing in place of Patrick Ah Van.
Setaimata Sa, Chris Bridge, Connor Farrell, Chris Houston and Corey Thompson will all make their home debuts.
Widnes Vikings: Chris Bridge, Kevin Brown, Hep Cahill, Chris Dean, Gil Dudson, Connor Farrell, Rhys Hanbury, Aaron Heremaia, Chris Houston, Macgraff Leuluai, Manase Manuokafoa, Stefan Marsh, Joe Mellor, Eamon O'Carroll, Charly Runciman, Setaimata Sa, Corey Thompson, Lloyd White, Matt Whitley.
Leeds Rhinos: Carl Ablett, Tom Briscoe, Rob Burrow, Adam Cuthbertson, Brett Delaney, Brett Ferres, Keith Galloway, Mitch Garbutt, Ashton Golding, Ryan Hall, Ash Handley, Zak Hardaker, Jimmy Keinhorst, Jordan Lilley, Joel Moon, Brad Singleton, Liam Sutcliffe, Josh Walters, Kallum Watkins.